Academic Surgical Congress Practice Presentations
Presenters: Drs. Sidrah Khan, Tanner Wilson, Elizabeth Andraska, Jillian Bonaroti, and JB Moses
Simmons Research Conferences
Cyclic GMP-AMP Synthase Contributes to Epithelial Homeostasis in Intestinal Inflammation Via Beclin-1 Mediated Autophagy / The Effect of NETs in Awakening Dormant Cancer Cells in the Tumor Microenvironment / The Effect of Simultaneous iNOS and COX2...
Cyclic GMP-AMP Synthase Contributes to Epithelial Homeostasis in Intestinal Inflammation Via Beclin-1 Mediated Autophagy
cGAS maintains intestinal epithelial homeostasis during human IBD and murine colitis by upregulating Beclin-1 mediated autophagy and preventing IEC death. Rescue of autophagy can attenuate the severity of colitis associated with cGAS deficiency.
Presenters: Dr. Sidrah Khan (advisor: Dr. Kevin Mollen)
Inflammasome-Mediated Effects of SARS-related proteins on Muscle Satellite Cells in Peripheral Arterial Disease
Presenter: Dr. Bowen Xie (mentor: Ulka Sachdev, MD)
This project aimed to evaluate whether peripheral arterial disease (PAD) potentiates the interaction and effects of SARS-related proteins in myoblasts, as well as the effects of these viral peptides on inflammasome function in PAD patients.
Extracellular Nucleotides, Nucleotide Receptors and Arteriogenesis
Presenter: Rohan Kulkarni, MD (Mentor: Dr. Ryan McEnaney)
Dr. Kulkarni will discuss in-vivo and ex-vivo models for determining how extracellular nucleotide receptor P2Y6 influences perfusion recovery, arteriogenesis, and gene-expression.
Whole-Genome DNA Methylation Patterns can Differentiate Trauma Patients from Healthy Controls: A Pilot Study
Presenter: Ruben Zamora, PhD
Recent Publications:
Therapeutic Implications of Modulating β-catenin in Cholestasis
Presenter: Kari Nejak-Bowen, MBA, PhD
TBA
Presenter: Dr. Laura Allen (mentor: Dr. Matthew Rosengart)
Elucidating a Mechanism for the Protective Effect of Exercise against Hemorrhagic Shock in Mice
Presenter: Jennifer Darby, MD (mentor: Dr. Tim Billiar)
This presentation will delve into the results of using single cell RNA sequencing analysis to characterize differences in gene expression patterns at the bone marrow monocyte level between exercised and sedentary mice in response to hemorrhagic shock.
Platelet Mitochondrial Studies in Trauma/Whole Blood Supernatant Characterization
Presenter: Jay Srinivasan, MD (mentors: Drs. Matthew Neal and Susan Shea)
Mitochondrial Approaches to Preservation of Cardiac Function
Presenter: Brett Kaufman, PhD
Dr. Kaufman’s background mitochondrial respiratory function and mitochondrial disorders. His talk will be centered on recent work on metabolic aspects of sudden cardiac arrest and diastolic dysfunction in mouse models and upon therapeutic intervention.
Background Reading: