Department of Surgery

Allan Tsung, MD

  • Professor and UPMC Chair in Surgery
  • Vice Chair of Research, Department of Surgery
  • Co-Director, UPMC Liver Cancer Center

Education & Training

  • BS, Cornell University
  • MD, SUNY Health Science Center at Brooklyn
  • Surgery Residency, UPMC
  • Research Fellowship, University of Pittsburgh
  • Hepatobiliary and Pancreas Surgery Fellowship, UPMC
  • Marshall Webster Physician Leadership Program, Katz Graduate School of Business, University of Pittsburgh

Representative Publications

Dr. Tsung's publications can be reviewed on PubMed.

Research, Clinical, and/or Academic Interests

The ongoing studies in the Tsung Lab focus on innate immunity and the damage-associated molecular pattern (DAMP) danger response, specifically, the role of DAMPs and pattern recognition receptors in injury-induced inflammation and tumorigenesis of primary and metastatic liver cancer. Dr. Tsung's seminal findings implicate high mobility group box protein 1 (HMGB1) as an early mediator following acute, local organ injury, as in liver ischemia and reperfusion (I/R). He has developed his research program based on the hypothesis that ischemic parenchymal cells mobilize and release nuclear HMGB1 as a way to notify adjacent immune cells of impending tissue injury. This, in turn leads to activation of an inflammatory response that when excessive, contributes to further tissue damage. These inflammatory responses can also alter the local microenvironment leading to cancer progression via tumor cell survival, expansion, and metastases. The Tsung Lab has recently demonstrated the novel finding that neutrophils can form neutrophil extracellular traps (NETs) in response to surgical stress to the liver (i.e. I/R) and that targeting NETs ameliorates the hepatic as well as systemic inflammation in mice. Their latest exciting findings demonstrate that increased NET formation following surgical stress of the liver also results in the acceleration of both the development and progression of metastatic disease. Because alterations in autophagy underlie mechanisms of a number of common hepatic diseases, Dr. Tsung is also interested in understanding the roles that autophagy can play in normal hepatic physiology as well as in pathophysiological conditions, including hepatocellular carcinoma and I/R liver injury. The combination of these studies will provide a more comprehensive understanding of how inflammatory pathways promote organ injury after ischemic insults and should prove useful in the design of novel therapies to minimize tissue damage and improve liver function in a variety of disease states.

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