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James F. Pingpank Jr., MD, FACS
Associate Professor
Pittsburgh, PA
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| Academic Appointments |
Temple University School of Medicine, July 1999-June 2001
University of Pittsburgh School of Medicine, August 2008-Present
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| Honors/Awards |
1987-Amherst College Student Research Grant
1987-1988-Ford Foundation Research Fellowship
1988 - 1989- John Woodruff Simpson Fellowship in Medicine
1997-University of Connecticut Department of Surgery, Resident Research Award
1998-Greater Hartford Vascular Society, Resident Paper Competition, Second Place
1998-Connecticut Chapter of the American board of Surgery\ American College of Surgeons Cancer Paper Competition, First Place
1999-Ludwig J. Pyrtek, M.D. Prize, Outstanding Resident in General Surgery, University of Connecticut School of Medicine
2000-Ross Residents and Fellows Research Conference Travel Award, San Diego, CA
2005-Technology Transfer Award, Center for Cancer Research, NCI, NIH
2007-Technology Transfer Award, Center for Cancer Research, NCI, NIH
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| Current Professional Activities |
University of Pittsburgh, Institutional Review Board, 2008 – Present
University of Pittsburgh, Technology and Innovative Practice Assessment Committee, 2011-Present
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| Selected Bibliography |
Hassan R, Remaley AT, Sampson ML, Zhang J, Cox DD, Pingpank JF, Alexander HR, Willingham M, Pastan I, Onda M. Detection and quantification of serum mesothelin in patients with mesothelioma and ovarian cancer using a mesothelin ELISA assay. Clin Cancer Res 2006; 12:447-453.
Royal RE, Pingpank JF. Surgical management of patients with peritoneal carcinomatosis arising from primary colorectal neoplasms. Seminars in Oncology 2008;35(2):183-91
Varghese S, Burness M, Xu H, Beresnev T, Pingpank JF, Alexander HR. Site-Specific Gene Expression Profiles and Novel Molecular Prognostic Factors in Patients with Lower Gastrointestinal Adenocarcinoma
Diffusely Metastatic to Liver or Peritoneum. Ann Surg Oncol. 2007; 12:3460-71.
Miao N, Pingpank JF, Alexander HR, Steinberg SM, Beresneva T, Quezado ZMN. Percutaneous Hepatic Perfusion in Patients with Metastatic Liver Cancer: Anesthetic, Hemodynamic, and Metabolic Considerations. Ann Surg Oncol. 2008;15(3):815-23.
Miao N, Pingpank JF, Alexander HR, Royal R, Steinberg SM, Quezado MM, Beresnev T, Quezado ZM. Cytoreductive surgery and continuous hyperthermic peritoneal perfusion in patients with mesothelioma and peritoneal carcinomatosis: hemodynamic, metabolic, and anesthetic considerations. Ann Surg Oncol. 2009: 16(2):334-44.
Alexander HR Jr, Bartlett DL, Libutti SK, Pingpank JF, Fraker DL, Royal R, Steinberg SM, Helsabeck CB, Beresneva TH. Analysis of factors associated with outcome in patients undergoing isolated hepatic perfusion for unresectable liver metastases from colorectal center. Ann Surg Onco2009
Jul;16(7):1852-9.l.
Pingpank JF. Melphalan for colorectal metastases to the liver. Clin Adv Hematol Oncol. 2010 Mar;8(3):175-7.. PMID: 20400932
8. Varghese S, Chen Z, Bartlett DL, Pingpank JF, Libutti SK, Steinberg SM, Wunderlich J, Alexander HR Jr Activation of the phosphoinositide-3-kinase and mammalian target of rapamycin signaling pathways are associated with shortened survival in patients with malignant peritoneal mesothelioma. Cancer. 2011 Jan 15;117(2):361-71. doi: 10.1002/cncr.25555. Epub 2010 Sep 13.PMID: 20839315
Thirunavukarasu P, Sukumar S, Sathaiah M, Mahan M, Pragatheeshwar KD, Pingpank JF,
Zeh H 3rd, Bartels CJ, Lee KK, Bartlett DL C-stage in Colon Cancer: Implications of Carcinoembryonic Antigen Biomarker in Staging, Prognosis, and Management. J Natl Cancer Inst. 2011 Mar 18. [Epub ahead of print]PMID: 21421861
Citrin D, Camphausen K, Wood BJ, Quezado M, Denobile J, Pingpank JF, Royal RE, Alexander HR, Seidel G, Steinberg SM, Shuttack Y, Libutti SK. A Pilot Feasibility Study of TNFerade™ Biologic with Capecitabine and Radiation Therapy Followed by Surgical Resection for the Treatment of Rectal Cancer Oncology. 2011 Mar 25;79(5-6):382-388.
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| Selected Review Articles, Chapters, and Textbooks |
Citrin DE, Pingpank JF. Diagnosis and Treatment of Peritoneal Carcinomatosis. In: Cancer. Principles and Practice of Oncology (8th Edition), DeVita VT, Lawrence T, Rosenberg SA (eds.), JB Lippincott , Philadelphia, PA, 2007.
Wood BJ, Pingpank JF. Vascular Access and Specialized Techniques of Drug Delivery. In: Cancer. Principles and Practice of Oncology (8th Edition), DeVita VT, Lawrence T, Rosenberg SA (eds.), JB Lippincott , Philadelphia, PA, 2007.
Heller CK, Pingpank JF, Libutti SK. Isolated Hepatic Perfusion and Percutaneous Hepatic Perfusion. In: Malignant Liver Tumors: Current and Emerging Therapies (Third Edition), Clavian PA (ed), Wiley-Blackwell, Oxford, UK, 2010.
Pingpank JF. Surgical Management of Metastases. In: University of Pittsburgh Textbook of Surgical Oncology; Bartlett DL (ed), Jaypee Brothers Publishing, New Delhi, India, 2010
Pingpank JF. Vascular Access and Specialized Techniques of Drug Delivery. In: Cancer. Principles and Practice of Oncology (9th Edition), DeVita VT, Lawrence T, Rosenberg SA (eds.), JB Lippincott , Philadelphia, PA, 2010.
Pingpank JF. Regional Therapy. In: Handbook of Anticancer Agents Pharmacokinetics and Pharmacodynamics (2nd Edition); Figg WD, McLeod H, Chau CH, Rudek M (eds), Springer, New York, NY, 2010.
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| Presentations and Abstracts at Scientific Meetings |
Soriano PA, Libutti SK, Pingpank JF, Beresenev T, Steinberg SM, Bartlett DL, Fraker DL, Helsabeck C, Alexander HR. Analysis of factors influencing outcome in patients with in transit malignant melanoma (MM) undergoing isolated limb perfusion (ILP) using standardized operative parameters with melphalan and biological agents. Presented (Abstract # 8006) at the 2006 Annual Meeting of American Society of Clinical Oncology, Atlanta, GA, June 2006.
Varghese S, Pingpank JF, Xu H, Cox D, Alexander HR. Gene expression profiling of malignant peritoneal mesothelioma identifies novel targets for therapeutic intervention. 8th International Conference of the International Mesothelioma Interest Group, Chicago, IL, October 2006
Alexander HR, Pingpank JF, Libutti SK, Bartlett DL, Fraker DL, Royal RE, Steinberg SM, Beresnev TH, Helsabeck CB. Analysis of Factors Associated With Outcome in Patients Undergoing Isolated Hepatic Perfusion (IHP) For Unresectable Liver Metastases (LM) from Colorectal Cancer (CRC). Presented (Abstract #14) at the 60th Annual Meeting of the Society of Surgical Oncology, Washington DC, March 2007.
Miao N, Beresnev T, Pingpank JF, Alexander HR, Quezado A. Perianesthetic course and anesthetic considerations for percutaneous hepatic perfusion in patients with metastatic cancer. Poster presentation at the Second International Symposium on Regional Cancer Therapies, San Juan, Puerto Rico, February 2007.
Pingpank JF, Royal RE, Kammula US, Kam AW, Wood BJ, Alexander HR, Libutti SK, Hughes MS, Ohl SE. High Dose Intra-Arterial Melphalan Delivered via Percutaneous Hepatic Perfusion (PHP) for Patients with Unresectable Hepatic Metastases from Primary Neuroendocrine Tumors. Presented at the American Hepato-Pancreato-Biliary Association Annual Meeting, Ft. Lauderdale, Florida, March 2008.
Pingpank JF, Libutti SK, Royal RE, Kammula US, Alexander HR, Hughes MS, Wood BJ, Kam AW, Ohl SE, Emery B. Impact of High-Dose Melphalan (MEL) administered via Hepatic Arterial Infusion for Patients with Unresectable Hepatic Metastases (LM) from Ocular Melanoma (OM). Poster presentation (Abstract #170) at the 2008 Gastrointestinal Cancer Symposium (ASCO-ASTRO-SSO-AGE), Orlando, FL, January 2008.
Pingpank JF, McCluskey K. Percutaneous hepatic perfusion (PHP) with melphalan for patients with unresectable hepatic metastases from ocular and cutaneous melanoma primary tumors. Poster presented at the Third Annual Meeting of the International Liver Cancer Association, Milan Italy, September 2009.
Breaux JA, Holtzman MP, Zeh HJ, Bartlett DL, Pingpank JF. Right colon resection is not required for lymph node staging or clearance in low grade appendiceal tumors. Presented at the Fifth International Symposium on Regional Cancer Therapies, San Juan, Puerto Rico, February, 2010.
Mavanur A, Bartlett DL, Holtzman MP, Pingpank JF, Zeh HJ. Hyperthermic intra-peritoneal chemoperfusion for patients with recurrent mucinous carcinomatosis. Presented at the Fifth International Symposium on Regional Cancer Therapies, San Juan, Puerto Rico, February, 2010.
Mavanur A, Bartlett DL, Holtzman MP, Pingpank JF, Zeh HJ. Hyperthermic intra-peritoneal chemoperfusion for patients with recurrent mucinous carcinomatosis. Presented at the Fifth International Symposium on Regional Cancer Therapies, San Juan, Puerto Rico, February, 2010.
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| Research Projects |
| Clinical Research: (Industry Support: Delcath Systems, Inc) My research involves novel techniques for the administration of regional chemotherapy delivery for patients with unresectable hepatic malignancies. At present, the 2 operative strategies we employ are an Isolated Hepatic Perfusion (IHP) performed via laparotomy and percutaneous hepatic perfusion. Both strategies employ intra-arterial melphalan. Patients treated include those with primary hepatic malignancies and metastatic colorectal and neuroendocrine tumors. Scientific correlates include pharmacokinectic analysis of drug delivery |
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