The main focus of the laboratory is to understand the role of the immune system in lung pathophysiologies, such as pulmonary hypertension. The presence of immune cells in patients’ pulmonary lesions points to a role of the immune system in this disease. The Bauer Lab is especially interested in understanding the role of endogenous innate immune mediators (i.e. HMGB1), and receptors (toll-like receptors), as well as the interplay between innate immune cells such as natural killer cells, neutrophils, and macrophages. Using a variety of rodent disease models coupled with genetically modified mice and cell culture models, the lab explores the role of the immune system in the pathogenesis of this disease. They further aim to learn lessons from cancer immunotherapies by applying their mechanisms to their lung pathophysiologies.
At a more basic scientific level, the Bauer Lab tries to get an in depth understanding of HMGB1’s interaction with toll-like receptors, its nuclear role, its travel through the three dimensional cell, and the purpose of HMGB1’s binding partners newly identified by themselves and their colleagues in the Department of Surgery.
Another interest of the lab is to advance their understanding of the immune system in inflammatory lung pathologies by collaborating with Dr. Carolyn Anderson in the Department of Radiology to image immune cells in their in vivo models using positron emission.
NW 607 UPMC Montefiore
Publications from the Bauer Lab can be viewed through PubMed.