Education & Training
- M.D., University of Kentucky, Lexington, KY, with distinction, 2013-2017
- B.S., Chemistry, Furman University, Greenville, SC, cum laude, 2009 - 2013
- Internship - General Surgery, University of Florida, Gainesville, FL, 2017 - 2024
- T32 Research Fellow – Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida, Gainesville, FL, 2020 - 2022
- Residency - General Surgery, University of Florida, Gainesville, FL, 2018 - 2024
Representative Publications
Brakenridge SC, Chen U, Loftus TJ, Ungaro R, Dirain M, Kerr A, Zhong L, Bacher R, Starostik P, Ghita G, Midic U, Darden DB, Fenner BP, Wacher J, Efron PA, Liesenfeld O, Sweeny TE, Moldawer LL. Evaluation of a Multivalent Transcriptomic Metric for Diagnosing Surgical Sepsis and Estimating Mortality Among Critically Ill Patients. JAMA Network Open. 2022.
Yonker LM, Badaki-Makun O, Arya P, Boribong BP, Moraru G, Fenner BP, Rincon JC, Hopke A, Rogers B, Hinson J, Fasano A, Lee L, Kehoe SM, Larson SD, Chavez H, Levin S, Moldawer LL, Irimia D. Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications. BMC Infectious Diseases. 2022.
Efron PA, Darden DB, Li EC, Munley J, Kelly L, Fenner BP, Nacionales DC, Ungaro RF, Dirain ML, Rincon J, Mankowski RT, Leeuwenburgh C, Moore FA, Brakenridge SC, Foster TC, Laitano O, Casadesus G, Moldawer LL, Mohr AM, Thomas RM. Sex differences associate with late microbiome alterations after murine surgical sepsis. J Trauma Acute Care Surg. 2022.
Kelly LS, Apple CG, Darden DB, Kannan KB, Pons EE, Fenner BP, Parvataneni HK, Hagen JE, Brakenridge SC, Efron PA, Mohr AM. Transcriptomic Changes Within Human Bone Marrow After Severe Trauma. Shock. 2022.
Darden DB, Kelly LS, Fenner BP, Moldawer LL, Mohr AM, Efron PA. Dysregulated Immunity and Immunotherapy after Sepsis. Journal of Clinical Medicine. 2021.
Fenner BP, Darden DB, Kelly LS, Rincon J, Brakenridge SC, Larson SD, Moore FA, Efron PA, Moldawer LL. Immunological Endotyping of Chronic Critical Illness After Severe Sepsis. Frontiers in Medicine. 2021.
Darden DB, Brakenridge SC, Efron PA, Ghita GL, Fenner BP, Kelly LS, Mohr AM, Moldawer LL, Moore FA. Biomarker Evidence of the Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) in Chronic Critical Illness (CCI) After Surgical Sepsis. Annals of Surgery. 2021.
Brakenridge SC, Starostik P, Ghita GL, Midic U, Darden DB, Fenner BP, Wacker J, Efron PA, Liesenfeld O, Sweeney TE, Moldawer LL. A transcriptomic severity metric that predicts clinical outcomes in critically ill surgical sepsis patients. Critical Care Explorations. 2021.
9. Kelly LS, Darden DB, Fenner BP, Efron PA, Mohr AM. The hematopoietic stem/progenitor cell response to hemorrhage, injury, and sepsis: a review of pathophysiology. Shock. 2021.
10. Darden DB, Ghita GL, Wang Z, Stortz JA, Lopez MC, Cox MC, Hawkins RB, Rincon JC, Kelly LS, Fenner BP, Ozrazgat-Baslanti T, Leeuwenburgh C, Bihorac A, Loftus TJ, Moore FA, Brakenridge SC, Baker HV, Bacher R, Mohr AM, Moldawer LL, Efron PA. Chronic critical illness elicits a unique circulating leukocyte transcriptome in sepsis survivors. Journal of Clinical Medicine. 2021.
Darden DB, Dong X, Brusko MA, Kelly LS, Fenner BP, Rincon JC, Dirain ML, Ungaro R, Nacionales D, Gauthier M, Kladde M, Brusko TM, Bihorac A, Moore FA, Loftus TJ, Bacher R, Moldawer LL, Mohr AM, Efron PA. A novel single cell RNA-seq analysis of non-myeloid circulating cells in late sepsis. Frontiers in Immunology. 2021.
Darden DB, Fenner BP, Foster T, Larson S, Efron PA. Chronic "sepsis brain" and regulatory T cells - A promising therapeutic target. Brain Behav Immun. 2021.
Darden DB, Ghita GL, Wang Z, Stortz JA, Lopez MC, Cox MC, Hawkins RB, Rincon JC, Kelly LS, Fenner BP, Ozrazgat-Baslanti T, Leeuwenburgh C, Bihorac A, Loftus TJ, Moore FA, Brakenridge SC, Baker HV, Bacher R, Mohr AM, Moldawer LL, Efron PA. Chronic Critical Illness Elicits a Unique Circulating Leukocyte Transcriptome in Sepsis Survivors. J. Clin Med. 2021.
Darden DB, Mira JC, Lopez MC, Stortz JA, Fenner BP, Kelly LS, Nacionales DC, Budharaju A, Loftus TJ, Baker HV, Moore FA, Brakenridge SC, Moldawer LL, Mohr AM, Efron PA. Identification of unique microRNA expression patterns in bone marrow hematopoietic stem and progenitor cells after hemorrhagic shock and multiple injuries in young and old adult mice. J Trauma Acute Care Surg. 2021.