Department of Surgery

Matthew Randall Rosengart, MD, MPH

  • Professor of Surgery and Critical Care Medicine
  • Vice Chair of Academic Training
  • Watson Family Chair in Surgery
  • Director, University of Pittsburgh Surgical Critical Care Fellowship Program
  • Co-Director, University of Pittsburgh Department of Surgery, Surgical Outcomes Research Center

The Rosengart Lab has a long-standing record of examining the role of innate immunity in the systemic response to injury and infection, with particular expertise in calcium-dependent mechanisms. The laboratory has focused upon the mechanisms involved in the inflammatory processes that define the response to injury in relevant sepsis and trauma models such as LPS-induced inflammation and organ dysfunction, cecal ligation and puncture (CLP) polymicrobial sepsis, warm hepatic ischemia/reperfusion (I/R) injury, and hemorrhagic shock. By employing diverse strategies such as in vivo siRNA to generate genetically engineered mice lacking key components of the calcium-sensitive CaMK cascade, high-speed depth resolved optical mapping of calcium transients, electron and fluorescent microscopy of subcellular organelle and protein trafficking, and study of the ramifications of calcium supplementation on inflammation and organ dysfunction, Dr. Rosengart has contributed to the understanding of calcium-dependent regulation and signaling during the inflammatory states of sepsis and injury. The translational perspective of his studies has provided mechanistic insight into the ramifications of the common practice of calcium supplementation in critical illness on the clinically relevant outcomes of organ failure and survival.

Education & Training

  • BA, The Johns Hopkins University
  • MD, University of Alabama at Birmingham
  • General Surgery Residency, University of Alabama at Birmingham
  • NIH/NRSA Fellowship in Molecular Biology, University of Washington
  • General Surgery Residency, University of Washington
  • MPH, University of Washington
  • Trauma/Surgical Critical Care Fellowship, University of Washington

Representative Publications

Dr. Rosengart's publications can be reviewed through PubMed.

Research, Clinical, and/or Academic Interests

  • The cellular and molecular biology of inflammation during sepsis in the context of host (murine and human) organ physiology and survival
    • Calcium signaling
    • Mitophagy
    • Biology of Aging
    • Diurnal rhythms and clock biology
    • Light therapy
  • A molecular and epidemiological evaluation of the practice of calcium supplementation in critical illness
  • Light in the biology of critical ill ness
  • Decision analysis and behavioral sciences in the care of the injured patient
  • Trauma system organization and infrastructure
  • Optimal management of critically ICU patients 

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