Department of Surgery

Simmons Research Conferences

"Transcriptomic-Guided Tumor Infiltrating Lymphocyte Therapy for Immune-Resistant Cancers"

Abstract: Most patients with metastatic cancer do not respond to immunotherapy using checkpoint inhibition, and thus alternative treatments are necessary. Metastatic uveal melanoma is a prototypic solid tumor with resistance to checkpoint inhibition. Our group has previously shown that a subset of uveal melanoma patients harbor tumor-reactive tumor infiltrating lymphocytes (TIL) in their metastases and that adoptive cell transfer (ACT) of these TIL could mediate a 35% objective response rate.